Chemotherapy effect on myocardial fibrosis markers in patients with gynecologic cancer and low cardiovascular risk

Background Patients with gynecologic cancers experience side effects of chemotherapy cardiotoxicity. We aimed to quantify cardiac magnetic resonance (CMR) markers myocardial fibrosis in patients cancer and low cardiovascular risk who undergo chemotherapy. Methods This study is part a registered clinical research. CMR T1 mapping was performed undergoing The results were compared those age-matched healthy control subjects. Results 68 (median age = 50 years) 30 subjects included. median number cycles 9.0 (interquartile range [IQR] 3.3–17.0). Extracellular volume fraction (ECV) (27.2% ± 2.7% vs. 24.5% 1.7%, P < 0.001) global longitudinal strain (−16.2% 2.8% −17.4% 2.0%, 0.040) higher controls. (>6 cycles) (n=41) had significantly lower intracellular mass indexed (ICMi) both (≤6 (n=27) 27.44 g/m 2 [IQR 24.03–31.15 ] 34.30 29.93–39.79 ]; 0.002) the group 32.79 27.74–35.76 0.002). two or more regimens ICMi one regimen (27.45 5.16 33.32 6.42 ; 33.02 5.52 0.001). associated an increase ECV (Standard regression coefficient [β] 0.383, 0.014) decrease (β -0.349, 0.009). Conclusion have diffuse extracellular expansion, which obvious cycles. Myocyte loss may be mechanism load. Clinical trial registration http://www.chictr.org.cn , identifier ChiCTR-DDD-17013450.